Group of Brain
Development and Disease
University of Copenhagen and Aarhus University
Our vision is to use stem cells and single cell technologies to understand the brain, brain development, disease and tissue development.
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Studying the evolution of the spatial processing system
We are studying conserved cell types and connectivity of the medial entorhinal cortex and its homologous brain regions in several species
Development of entorhinal neurons for studying Alzheimer’s disease
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We have developed a protocol to create entorhinal stellate cell-like cells from human induced pluripotent stem cells that we aim to use for studying Alzheimer’s disease. This cell type is one of the first cell types to be affected very early on in the disease
Characterizing the cell types within the medial entorhinal cortex to better understand spatial processing.
We are characterizing the properties of cells in the superficial layers of the medial entorhinal cortex by measuring their electrical properties and their gene expression profiles by using a technology called patch-seq.
Developing multiomic technologies
We are producing novel tools for the neuroscience and cardiovascular fields that enables researchers to capture electrical recordings and spatial transcriptomic data in individual cells.
Cultivating clean meat using embryonic stem cells
We are creating protocols for producing muscle from embryonic stem cells (shown below) derived from cows for the purposes of optimizing clean meat production.
Studying the development of the entorhinal cortex
We are studying the mechanisms that control how the entorhinal cortex is produced during early development. This region of the brain develops differently than the rest of the cortex.